Pristiq withdrawal, like withdrawal from many other antidepressants, can be a bitch.

However, because Pristiq isn’t an addictive drug, it’s not quite called withdrawal — it’s actually called antidepressant discontinuation syndrome.

Thankfully, it only appears in about 20% of people, so if you’re taking Pristiq, you shouldn’t be as worried about it as you might be.

Pristiq, also known as desvenlafaxine, is an antidepressant that I’ve taken in one form or another on and off for the past 11 years. 

It’s an SNRI (serotonin-norepinephrine reuptake inhibitor) and is, for whatever reason, the type of antidepressant that works best for me.

Here’s what Pristiq withdrawal is like.

Pristiq Withdrawal Symptoms

If you’re one of the unlucky 1 in 5 people whose body becomes physically dependent on Pristiq, there are a number of symptoms you might experience, including:

  • flu-like symptoms
  • insomnia
  • nausea
  • imbalance
  • sensory disturbances
  • hyperarousal
  • brain zaps

Also, and this probably doesn’t come as a shock to you, but you can also find that your depression comes back.

If you suffer from major depressive disorder (MDD) like I do, one of the worst things you can probably do is to stop taking Pristiq or any other antidepressant.

Don’t get me wrong — all the symptoms of Pristiq withdrawal suck ass — but the one problem that’s much more important to worry about is your depression coming back.

My Biggest Symptom of Pristiq Withdrawal Was Depression

When I was 26 years old, I got sober from a wide variety of drugs.

It’s easier to say what I wasn’t abusing because I was getting high on so many different substances.

When I got sober, my depression came back like a son of a bitch. It was intense.

I hadn’t felt depression like that in a long time because I had been abusing opiates, which are, among all the fucked up things they do, actually great antidepressants.

So I went to a psychiatrist, and I got back on some antidepressants that I knew worked best for me — SNRIs.

I was started on an SNRI called Effexor, and though it worked great, it gave me terrible night sweats.

Because of this, I decided, in my incredible wisdom, that it would be a good idea for me to stop taking my antidepressants without consulting my psychiatrist.

As you might imagine, this didn’t go very well.

Now, because I worked the 12 steps rigorously at the time, especially step 12, my depression actually seemed to be under control for a while.

I’ll admit that it helped a lot for me to be helping others. I was also busy with school and working, so I didn’t really notice what was happening.

My depression was coming back.

This went on for about 8 years. I continued to work the 12 steps, I continued to help a lot of people, I worked and went to school, eventually getting three degrees.

I was so preoccupied with life that I didn’t realize how deeply depressed I had become.

When I finished school (finally) and got married, and everything started to settle down, I finally felt the depression for the first time in a long time.

That had been the biggest effect of my Effexor withdrawal — I became depressed again.

Funny how that works. Who would have guessed?

So I decided that I needed to do more than just work the 12 steps.

I decided I needed to go to a psychiatrist.

Getting on Pristiq

When I told the psychiatrist that SNRIs seemed to work best for me, she suggested Pristiq.

I’d never taken it before, but I was open-minded.

I started a low dose of Pristiq so that I could see how it worked, and I didn’t get much out of it — if anything. I was still deeply depressed.

I told the psychiatrist, and she told me that we could try bumping up the dosage because this was just a starter dosage that I was on.

We did that, and I finally started to get some results, but I still felt depressed — just not as deeply depressed as I had.

Before, I just had kind of felt like I didn’t want to exist.

Now, I was okay with existing, but not by a lot.

So the Pristiq was treating my depression, that was clear, but I needed a higher dose. I got up to 100mg a day, and I found that this was enough to treat my depression.

I no longer felt like life sucked and that nothing was worthwhile — I felt okay.

I’m not going to lie and say that depression is always treated completely by antidepressants. It’s not like I started waking up with a smile on my face and that everything in life felt wonderful.

I just felt okay again. Like I could deal with life and not have it kick my ass day after week after month after year.

This might be part of the problem and why I felt the symptoms of Pristiq withdrawal when I would miss a dose.

Pristiq Withdrawal Can Start Fast — In My Experience, After 24 Hours

When I started taking Pristiq at that high dose, I first had to realize that I wasn’t going to be made incredibly happy by the drug — it was just going to level me out and treat my major depressive disorder.

However, and it took a while for me to realize this, it was also going to help with my bipolar disorder.

It was probably another six months before I got on medicine for my bipolar, but I found that the antidepressant worked well for part of it.

I also learned, thankfully, that I couldn’t do what I’d done in the past.

I couldn’t just stop taking Pristiq.

It would be stupid.

Really stupid.

But every now and then, I would forget my dose.

Once, I forgot to put Pristiq in my med minder, and I ended up withdrawing from Pristiq for 3 days straight.

That should tell you a little bit about how Pristiq withdrawal really isn’t that bad.

Yeah, any sort of withdrawal sucks, but I’ve gone through serious withdrawal from heroin, so I can honestly say that Pristiq withdrawal isn’t nearly as bad as that.

I didn’t notice for 3 days that I wasn’t taking my meds, but I was definitely experiencing the symptoms of Pristiq withdrawal.

For example, I was getting the brain zaps pretty badly. I didn’t even know what those were because I’d never experienced them before.

Even when I was withdrawing from Xanax, I didn’t get brain zaps — I just went straight to seizures.

The brain zaps kind of feel like a little shock. You sort of have a very tiny blackout and then sort of come to. It’s like your whole head gets filled with electricity for a quarter of a second — a little zap.

I also started feeling those flu-like symptoms, but they weren’t nearly as intense as the severe flu-like feelings you get when you come off of heroin.

I just felt kind of generally ill.

I didn’t really want to eat. My stomach was kind of off feeling. I was tired. That was about it.

The symptoms of Pristiq withdrawal are only supposed to l–2 weeks, so frankly, I don’t think it would be that bad to come off of if I were to go through the entire process.

Don’t get me wrong — it wouldn’t be great to go through either — it just wouldn’t be terrible. You could probably keep working or going to school or whatever while doing it.

How to Deal With Symptoms

You might want to come off for one reason or another that makes sense for you. If you’re going to come off your antidepressants, make sure you do it under the care of a doctor. I won’t give medical advice here–that’s something your doctor will have to do.

Have you gone through Pristiq withdrawal or are you worried you’re going to have to withdraw from it soon? Tell me your story in the comments.

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1 year ago

Thank you so muh for posting this. I too went from effexer to pristiq. I also get the withdrawal symptoms within a few hours of a missed dose. I was at 100mg for many years. Went to 50mg for 3 months. Now I’m on 25mg for about 10 days. I’m going to completely discontinue very soon. I hope i make it this time. How long does the irritability, brain zaps and dizziness last??

11 months ago
Reply to  Holly

How are you doing now? It’s been months !

1 year ago

Going through Pristiq withdrawal myself and even with carefully tapering down over a month the side effects are atrocious, especially the brain zaps.

I wish I’d never taken it, definitely not worth it for me. I now use exercise to treat depression and it’s far more effective, not to mention no side effects.

1 year ago

Thank you for sharing your story. Your experience and insight have helped me greatly during my withdrawal. I, too have found weed to be an invaluable resource during detox. It lessens the symptoms but I also think it helps to reset brain chemistry more quickly. This is just my personal observation and not based on anything I’ve read. I also used it to help detox off of benzodiazepines prior to my Pristiq withdrawal.
Even though detox is difficult, it is so wonderful to feel again. I think learning to deal with feelings through counseling and meditation helped me feel strong enough to detox and experience life sober. Thank you, again for taking the time to share your story.

1 year ago

I started having joint, bone and muscles pain in some of my big muscles of pain after months on the 50 mg dose. I started thinking maybe arthritis or fibromyalgia. Now I am on the 25mg and if I miss a dose I get very irritable. The joint pain is mostly in my hands , it’s constant and at times gets worse or just random sharp pains in my wrists, arms. Does this sound familiar to anyone with coming off Desvenlafaxine??

11 months ago

I’ve been on 50mg for about 5 months and just went down to 25 mg a week ago. The tingling in your hands and feet is insane. Joint pain follows, I’ve experienced sharp pains up and down my arms and legs. It apparently happens to 20% of ppl who take pristiq.

6 months ago

I am currently suffering seriously bad withdrawals from pristiq, I’ve never been on heroin so don’t have a comparison there, but i guarantee there is no way i can go to work or function beyond the absolute basics, most ofthetimei cant stand up or movemy eyes tothe side without my stomach turningor feeling like ill pass out 🙁 I’ve been on anti depressants for 20 years and was only a teenager when it was first prescribed to treat PTSD, co morbid and major depressive disorder. It started with quite a small dose but for a number of years now has been 200mg a day. Two weeks ago my doctor prescribed me bupropion to take ontop of the pristiq, these two drugs do not work together and I had a major reaction leaving me with severe tiredness, dizziness, nausea, diohrea, nightmares, sinus and lung infections with pollups and rash in the back of my mouth and around rib area. I stopped taking the bupropion and Due to feeling so sick missed a day of pristiq.. when I tried to take the pristiq again-only 100mg- I was violently ill, I tried again the next day and same again, I can’t take them anymore so I have been plunged into cold Turkey withdrawal 🙁 I spoke to my doctor and he brushed it off saying id be ok and wrote me a script for antibiotics to clear the infections and rash.. I’m in week two now and on my own, neurofen helps with the headaches and muscle pain (that randomly selects a different body part to attack each day ) but the rest is a constant battle, i don’t feel depressed in the way I used to but I’m so sick and exhausted and teary all the time I sometimes doubt I can keep doing this..
your story has been really inspiring for me and leant me strength and determination to keep pushing through, unfortunately I dont have weed to help haha but i do have diazepam so hopefully that will help a little.. thankyou so much for sharing your story and giving me hope it’s greatly appreciated

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